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・ Phosphoramidite
・ Phosphoramidon
・ Phosphorane
・ Phosphorene
・ Phosphorescence
・ Phosphorescent (band)
・ Phosphorescent Harvest
・ Phosphorescent organic light-emitting diode
・ Phosphoria Formation
・ Phosphoribokinase
・ Phosphoribosyl pyrophosphate
・ Phosphoribosyl-AMP cyclohydrolase
・ Phosphoribosyl-ATP diphosphatase
・ Phosphoribosyl-N-formylglycineamide
・ Phosphoribosylamine
Phosphoribosylamine—glycine ligase
・ Phosphoribosylaminoimidazole carboxylase
・ Phosphoribosylaminoimidazole synthetase
・ Phosphoribosylaminoimidazolecarboxamide formyltransferase
・ Phosphoribosylaminoimidazolesuccinocarboxamide
・ Phosphoribosylaminoimidazolesuccinocarboxamide synthase
・ Phosphoribosylanthranilate isomerase
・ Phosphoribosylformylglycinamidine synthase
・ Phosphoribosylglycinamide formyltransferase
・ Phosphoribosyltransferase
・ Phosphoribulokinase
・ Phosphoric
・ Phosphoric acid
・ Phosphoric acid fuel cell
・ Phosphoric acids and phosphates


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Phosphoribosylamine—glycine ligase : ウィキペディア英語版
Phosphoribosylamine—glycine ligase

In enzymology, ''phosphoribosylamine-glycine ligase'', also known as glycinamide ribonucleotide synthetase (GARS), () is an enzyme that catalyzes the chemical reaction
:ATP + 5-phospho-D-ribosylamine + glycine \rightleftharpoons ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
which is the second step in purine biosynthesis.
The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.
In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). The purD genes often contain PurD RNA motif in their 5' UTR. In yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5/7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS). In higher eukaryotes,including humans,〔 GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART),〔 forming GARS-AIRS-GART.
== Nomenclature ==

The systematic name of this enzyme class is 5-phospho-D-ribosylamine:glycine ligase (ADP-forming). Other names in common use include:
* phosphoribosylglycinamide synthetase,
* glycinamide ribonucleotide synthetase,
* phosphoribosylglycineamide synthetase,
* glycineamide ribonucleotide synthetase,
* 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase,
* 5'-phosphoribosylglycinamide synthetase, and
* GAR synthetase.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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